Genomic variation, prospective accuracy, and prevalence of previous malignancies in non-small cell lung cancer (NSCLC) associated with alterations in PIK3CA

• Author Details:   
• Tshetiz Dahal ^*

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Context: Although non-small cell lung cancer (NSCLC) has been linked to somatic mutations of the PIK3CA gene, nothing is known about their biological significance. The purpose of this study was to evaluate the clinical and genetic features of PIK3CA-mutated NSCLC.
Materials and Methods: Using dideoxy-sequencinb and next-generation sequencing (NGS), tumour tissue obtained successively from 1144 NSCLC patients in a molecular screening network between February 2023 and April 2024 was examined for PIK3CA mutations. A control group of PIK3CA- wild-type patients is compared with the clinical, pathological, and genetic traits of PIK3CA-mutated patients.
Results: We found 42 (3.7%) patients with PIK3CA mutations in exons 9 and 20 out of the 1144 patients in the cohort. The frequency of these mutations was higher in squamous cell carcinoma (8.9%) than in adenocarcinoma (2.9%, p<0>
Conclusion: The findings indicate that PIK3CA-mutated NSCLC is a clinically and genetically diverse grouping of adenocarcinomas and squamous cell carcinomas, with a higher frequency of these mutations in the latter. Following surgery or systemic therapy, survival is unaffected by PIK3CA mutations. However, persons with a history of cancer often acquire lung cancer with a PIK3CA mutation.

Keywords: Non-small cell lung cancer, PIK3CA, Mutation, Lung cancer, PI3K